News & Meida

Our recent research on Bio-sensor has been featured in Kwangwoon University news portal. The research work entitled,"A Polyallylamine Anchored Amine‐Rich Laser‐Ablated Graphene Platform for Facile and Highly Selective Electrochemical IgG Biomarker Detection" is about a facile, cost‐effective, disposable, and highly selective electrochemical immunosensing platform is developed based on cationic polyelectrolyte polyallylamine (PAAMI) anchored laser‐ablated graphene (LAG). In this work, for the first time PAAMI is introduced to stabilize LAG flakes, while retaining the intrinsic thermal and electronic properties of the substrate by noncovalent π–π interaction and electrostatic physical absorption. The sensing platform offers a suitable number of anchoring sites for the immobilized antibodies by providing -NH₂ functional groups. Under optimized conditions, the sensing platform exhibits a linear range of 0.012–15 and 15–352 ng mL⁻¹ with a limit of detection of 6 pg mL⁻¹ for IgG detection with high selectivity. Based on the analysis, the developed immunosensing platform can be used for point‐of‐care detection of IgG in clinical diagnostic centers. Furthermore, the developed strategy is well suited for the detection of other cancer biomarkers after immobilizing the relevant antibodies.

The research work is published in highly impacted journal "Advanced Functional Materials" in 06 April 2020. This work was supported by the Bio & Medical Technology Development Program of the NRF grant funded by the Korean government (MSIT) (NRF‐2017M3A9F1031270). Furthermore, the authors are grateful to the members of the MiNDaP (Micro/Nano Devices and Packaging Lab.) group for their technical support and discussion.

Detail news can be read at Kwangwoon University News Portal link.